AustralieFrV1, Main, Exploration, bibRecord, 00B219

Differences between graft product and donor side effects following bone marrow or stem cell donation

Identifieur interne : 00B219 ( Main/Exploration ); précédent : 00B218; suivant : 00B220

Differences between graft product and donor side effects following bone marrow or stem cell donation

Auteurs : G. Favre [Suisse] ; M. Beksac [Turquie] ; A. Bacigalupo [Italie] ; T. Ruutu [Finlande] ; A. Nagler [Israël] ; E. Gluckman [France] ; N. Russell [Royaume-Uni] ; J. Apperley [Royaume-Uni] ; J. Szer [Australie] ; K. Bradstock [Australie] ; A. Buzyn [France] ; J. Matcham [Royaume-Uni] ; A. Gratwohl [Suisse] ; N. Schmitz [Allemagne]

Source :

Bone marrow transplantation : (Basingstoke) [ 0268-3369 ] ; 2003.

RBID : Pascal:04-0155867

Descripteurs français

Pascal (Inist)
- Homogreffe, Cellule hématopoïétique, Cellule souche, Moelle osseuse, Sang, Cellule sanguine, Donneur apparenté, Leucophérèse, Mobilisation, Filgrastim, Qualité vie, Sécurité, Homme.
Wicri :
- topic : Cellule souche, Homme.

English descriptors

KwdEn :
- Blood, Blood cell, Bone marrow, Filgrastim, Hematopoietic cell, Homograft, Human, Leukapheresis, Mobilization, Quality of life, Related donor, Safety, Stem cell.

Abstract

We report graft product stem cell yields and donor safety results of a randomized multicenter study comparing allogeneic peripheral blood stem cell (PBSC) PBSC transplantation with BM transplantation. Matched HLA-identical sibling donors (n = 329) were randomized to filgrastim-mobilized PBSC or bone marrow (BM) donation groups. Median yields per kg recipient weight of CD34⁺ cells, T cells, and natural killer (NK) cells, respectively, were approximately two-fold, eight-fold, and greater than eight-fold in the PBSC group than in the BM group (CD34⁺ cells, 5.8 x 10⁶/kg vs 2.7 × 10⁶/kg; T cells, 300.1 × 10⁶/kg vs 35.7 x 10⁶/kg; NK cells, 28.2 × 10⁶/kg vs 3.6 × 10⁶/kg; P<0.001 for each). In connection with the cell collection procedures, PBSC donors spent a shorter median time in hospital than BM donors (0 vs 2 days; median difference -2 days, 95% Cl -2 to 2) and had fewer median days of restricted activity (2 vs 6 days; median difference -3 days, 95% CI -4 to 2). Overall, 65% of PBSC donors and 57% of BM donors reported at least one adverse event (AE), most of which were transient, mild-moderate in severity, and without clinical sequelae. PBSC donors experienced predominantly filgrastim-related AEs, while BM donors experienced predominantly harvest-related AEs.

Affiliations:

Allemagne, Australie, Finlande, France, Israël, Italie, Royaume-Uni, Suisse, Turquie
Angleterre, Grand Londres, Hambourg, Victoria (État), Île-de-France
Hambourg, Londres, Melbourne, Paris

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 005007
to stream PascalFrancis, to step Curation: 001107
to stream PascalFrancis, to step Checkpoint: 005003
to stream Main, to step Merge: 00BF88
to stream Main, to step Curation: 00B219

Le document en format XML

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<sZ>14 aut.</sZ>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Differences between graft product and donor side effects following bone marrow or stem cell donation</title>
<author><name sortKey="Favre, G" sort="Favre, G" uniqKey="Favre G" first="G." last="Favre">G. Favre</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Hematology and Hematology Laboratory, Kantonsspital Basel</s1>
<s2>Basel</s2>
<s3>CHE</s3>
<sZ>1 aut.</sZ>
<sZ>13 aut.</sZ>
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<country>Suisse</country>
<wicri:noRegion>Basel</wicri:noRegion>
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<author><name sortKey="Beksac, M" sort="Beksac, M" uniqKey="Beksac M" first="M." last="Beksac">M. Beksac</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Hematology/ Oncology, Ankara University</s1>
<s2>Ankara</s2>
<s3>TUR</s3>
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</inist:fA14>
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<sZ>3 aut.</sZ>
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<country>Italie</country>
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<author><name sortKey="Ruutu, T" sort="Ruutu, T" uniqKey="Ruutu T" first="T." last="Ruutu">T. Ruutu</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Medicine, Helsinki University Central Hospital</s1>
<s2>Helsinki</s2>
<s3>FIN</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
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<author><name sortKey="Nagler, A" sort="Nagler, A" uniqKey="Nagler A" first="A." last="Nagler">A. Nagler</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Bone Marrow Transplantation, Hadassah University Hospital</s1>
<s2>Jerusalem</s2>
<s3>ISR</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Israël</country>
<wicri:noRegion>Jerusalem</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gluckman, E" sort="Gluckman, E" uniqKey="Gluckman E" first="E." last="Gluckman">E. Gluckman</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Hematology, Hopital St Louis</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Russell, N" sort="Russell, N" uniqKey="Russell N" first="N." last="Russell">N. Russell</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Haematology, Nottingham City Hospital</s1>
<s2>Nottingham</s2>
<s3>GBR</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Nottingham</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Apperley, J" sort="Apperley, J" uniqKey="Apperley J" first="J." last="Apperley">J. Apperley</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Department of Haematology, Imperial College, Hammersmith Hospital</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Szer, J" sort="Szer, J" uniqKey="Szer J" first="J." last="Szer">J. Szer</name>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Bone Marrow Transplant Unit, Royal Melbourne Hospital</s1>
<s2>Melbourne</s2>
<s3>AUS</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bradstock, K" sort="Bradstock, K" uniqKey="Bradstock K" first="K." last="Bradstock">K. Bradstock</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Blood and Marrow Transplantation Services, Westmead Hospital</s1>
<s2>Westmead</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Westmead</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Buzyn, A" sort="Buzyn, A" uniqKey="Buzyn A" first="A." last="Buzyn">A. Buzyn</name>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Hematologie Adultes, Hopital Necker</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Matcham, J" sort="Matcham, J" uniqKey="Matcham J" first="J." last="Matcham">J. Matcham</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Amgen Ltd.</s1>
<s2>Cambridge</s2>
<s3>GBR</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Amgen Ltd.</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gratwohl, A" sort="Gratwohl, A" uniqKey="Gratwohl A" first="A." last="Gratwohl">A. Gratwohl</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Hematology and Hematology Laboratory, Kantonsspital Basel</s1>
<s2>Basel</s2>
<s3>CHE</s3>
<sZ>1 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Suisse</country>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schmitz, N" sort="Schmitz, N" uniqKey="Schmitz N" first="N." last="Schmitz">N. Schmitz</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Department of Hematology, AK St Georg</s1>
<s2>Hamburg</s2>
<s3>DEU</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Bone marrow transplantation : (Basingstoke)</title>
<title level="j" type="abbreviated">Bone marrow transplant. : (Basingstoke)</title>
<idno type="ISSN">0268-3369</idno>
<imprint><date when="2003">2003</date>
</imprint>
</series>
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<seriesStmt><title level="j" type="main">Bone marrow transplantation : (Basingstoke)</title>
<title level="j" type="abbreviated">Bone marrow transplant. : (Basingstoke)</title>
<idno type="ISSN">0268-3369</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Blood</term>
<term>Blood cell</term>
<term>Bone marrow</term>
<term>Filgrastim</term>
<term>Hematopoietic cell</term>
<term>Homograft</term>
<term>Human</term>
<term>Leukapheresis</term>
<term>Mobilization</term>
<term>Quality of life</term>
<term>Related donor</term>
<term>Safety</term>
<term>Stem cell</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Homogreffe</term>
<term>Cellule hématopoïétique</term>
<term>Cellule souche</term>
<term>Moelle osseuse</term>
<term>Sang</term>
<term>Cellule sanguine</term>
<term>Donneur apparenté</term>
<term>Leucophérèse</term>
<term>Mobilisation</term>
<term>Filgrastim</term>
<term>Qualité vie</term>
<term>Sécurité</term>
<term>Homme</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Cellule souche</term>
<term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We report graft product stem cell yields and donor safety results of a randomized multicenter study comparing allogeneic peripheral blood stem cell (PBSC) PBSC transplantation with BM transplantation. Matched HLA-identical sibling donors (n = 329) were randomized to filgrastim-mobilized PBSC or bone marrow (BM) donation groups. Median yields per kg recipient weight of CD34<sup>+</sup>
 cells, T cells, and natural killer (NK) cells, respectively, were approximately two-fold, eight-fold, and greater than eight-fold in the PBSC group than in the BM group (CD34<sup>+</sup>
 cells, 5.8 x 10<sup>6</sup>
/kg vs 2.7 × 10<sup>6</sup>
/kg; T cells, 300.1 × 10<sup>6</sup>
/kg vs 35.7 x 10<sup>6</sup>
/kg; NK cells, 28.2 × 10<sup>6</sup>
/kg vs 3.6 × 10<sup>6</sup>
/kg; P<0.001 for each). In connection with the cell collection procedures, PBSC donors spent a shorter median time in hospital than BM donors (0 vs 2 days; median difference -2 days, 95% Cl -2 to 2) and had fewer median days of restricted activity (2 vs 6 days; median difference -3 days, 95% CI -4 to 2). Overall, 65% of PBSC donors and 57% of BM donors reported at least one adverse event (AE), most of which were transient, mild-moderate in severity, and without clinical sequelae. PBSC donors experienced predominantly filgrastim-related AEs, while BM donors experienced predominantly harvest-related AEs.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Finlande</li>
<li>France</li>
<li>Israël</li>
<li>Italie</li>
<li>Royaume-Uni</li>
<li>Suisse</li>
<li>Turquie</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
<li>Hambourg</li>
<li>Victoria (État)</li>
<li>Île-de-France</li>
</region>
<settlement><li>Hambourg</li>
<li>Londres</li>
<li>Melbourne</li>
<li>Paris</li>
</settlement>
</list>
<tree><country name="Suisse"><noRegion><name sortKey="Favre, G" sort="Favre, G" uniqKey="Favre G" first="G." last="Favre">G. Favre</name>
</noRegion>
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   |texte=   Differences between graft product and donor side effects following bone marrow or stem cell donation
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	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les relations entre la France et l'Australie

Differences between graft product and donor side effects following bone marrow or stem cell donation

Differences between graft product and donor side effects following bone marrow or stem cell donation

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